Telaprevir twice daily is noninferior to telaprevir every 8 hours for patients with chronic hepatitis C.
Identifieur interne : 003477 ( Main/Exploration ); précédent : 003476; suivant : 003478Telaprevir twice daily is noninferior to telaprevir every 8 hours for patients with chronic hepatitis C.
Auteurs : Maria Buti [Espagne] ; Kosh Agarwal [Royaume-Uni] ; Yves Horsmans [Belgique] ; William Sievert [Australie] ; Ewa Janczewska [Pologne] ; Stefan Zeuzem [Allemagne] ; Lisa Nyberg [États-Unis] ; Robert S. Brown [États-Unis] ; Christophe Hézode [France] ; Mario Rizzetto [Italie] ; Raymundo Paraná [Brésil] ; Sandra De Meyer [Belgique] ; Ralph De Masi [États-Unis] ; Donghan Luo [États-Unis] ; Kirk Bertelsen [États-Unis] ; James Witek [États-Unis]Source :
- Gastroenterology [ 1528-0012 ] ; 2014.
Descripteurs français
- KwdFr :
- ARN viral (sang), Adulte, Adulte d'âge moyen, Antiviraux (administration et posologie), Antiviraux (effets indésirables), Antiviraux (usage thérapeutique), Association de médicaments, Calendrier d'administration des médicaments, Céphalée (épidémiologie), Fatigue (épidémiologie), Femelle, Génotype, Hepacivirus (génétique), Humains, Hépatite C chronique (sang), Hépatite C chronique (traitement médicamenteux), Incidence, Interféron alpha (effets indésirables), Interféron alpha (usage thérapeutique), Mâle, Nausée (épidémiologie), Oligopeptides (administration et posologie), Oligopeptides (effets indésirables), Oligopeptides (usage thérapeutique), Polyéthylène glycols (effets indésirables), Polyéthylène glycols (usage thérapeutique), Protéines recombinantes (effets indésirables), Protéines recombinantes (usage thérapeutique), Relation dose-effet des médicaments, Ribavirine (effets indésirables), Ribavirine (usage thérapeutique), Résultat thérapeutique.
- MESH :
- administration et posologie : Antiviraux, Oligopeptides.
- effets indésirables : Antiviraux, Interféron alpha, Oligopeptides, Polyéthylène glycols, Protéines recombinantes, Ribavirine.
- génétique : Hepacivirus.
- sang : ARN viral, Hépatite C chronique.
- traitement médicamenteux : Hépatite C chronique.
- usage thérapeutique : Antiviraux, Interféron alpha, Oligopeptides, Polyéthylène glycols, Protéines recombinantes, Ribavirine.
- épidémiologie : Céphalée, Fatigue, Nausée.
- Adulte, Adulte d'âge moyen, Association de médicaments, Calendrier d'administration des médicaments, Femelle, Génotype, Humains, Incidence, Mâle, Relation dose-effet des médicaments, Résultat thérapeutique.
English descriptors
- KwdEn :
- Adult, Antiviral Agents (administration & dosage), Antiviral Agents (adverse effects), Antiviral Agents (therapeutic use), Dose-Response Relationship, Drug, Drug Administration Schedule, Drug Therapy, Combination, Fatigue (epidemiology), Female, Genotype, Headache (epidemiology), Hepacivirus (genetics), Hepatitis C, Chronic (blood), Hepatitis C, Chronic (drug therapy), Humans, Incidence, Interferon-alpha (adverse effects), Interferon-alpha (therapeutic use), Male, Middle Aged, Nausea (epidemiology), Oligopeptides (administration & dosage), Oligopeptides (adverse effects), Oligopeptides (therapeutic use), Polyethylene Glycols (adverse effects), Polyethylene Glycols (therapeutic use), RNA, Viral (blood), Recombinant Proteins (adverse effects), Recombinant Proteins (therapeutic use), Ribavirin (adverse effects), Ribavirin (therapeutic use), Treatment Outcome.
- MESH :
- chemical , administration & dosage : Antiviral Agents, Oligopeptides.
- chemical , adverse effects : Antiviral Agents, Interferon-alpha, Oligopeptides, Polyethylene Glycols, Recombinant Proteins, Ribavirin.
- chemical , blood : RNA, Viral.
- chemical , therapeutic use : Antiviral Agents, Interferon-alpha, Oligopeptides, Polyethylene Glycols, Recombinant Proteins, Ribavirin.
- blood : Hepatitis C, Chronic.
- drug therapy : Hepatitis C, Chronic.
- epidemiology : Fatigue, Headache, Nausea.
- genetics : Hepacivirus.
- Adult, Dose-Response Relationship, Drug, Drug Administration Schedule, Drug Therapy, Combination, Female, Genotype, Humans, Incidence, Male, Middle Aged, Treatment Outcome.
Abstract
We performed an open-label, multicenter, phase 3 study of the safety and efficacy of twice-daily telaprevir in treatment-naive patients with chronic hepatitis C virus (HCV) genotype 1 infection, including those with cirrhosis.
DOI: 10.1053/j.gastro.2013.11.047
PubMed: 24316262
Affiliations:
- Allemagne, Australie, Belgique, Brésil, Espagne, France, Italie, Pologne, Royaume-Uni, États-Unis
- Angleterre, Bahia, Californie, Catalogne, District de Darmstadt, Hesse (Land), New Jersey, Piémont, Région de Bruxelles-Capitale, Victoria (État), État de New York, Île-de-France
- Barcelone, Bruxelles, Créteil, Francfort-sur-le-Main, Melbourne, Turin
Links toward previous steps (curation, corpus...)
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Le document en format XML
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<author><name sortKey="Hezode, Christophe" sort="Hezode, Christophe" uniqKey="Hezode C" first="Christophe" last="Hézode">Christophe Hézode</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Telaprevir twice daily is noninferior to telaprevir every 8 hours for patients with chronic hepatitis C.</title>
<author><name sortKey="Buti, Maria" sort="Buti, Maria" uniqKey="Buti M" first="Maria" last="Buti">Maria Buti</name>
<affiliation wicri:level="3"><nlm:affiliation>Liver Unit, Department of Internal Medicine, Hospital Valle Hebron and Ciberehd del Institut Carlos III, Barcelona, Spain. Electronic address: mbuti@vhebron.net.</nlm:affiliation>
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<author><name sortKey="Agarwal, Kosh" sort="Agarwal, Kosh" uniqKey="Agarwal K" first="Kosh" last="Agarwal">Kosh Agarwal</name>
<affiliation wicri:level="2"><nlm:affiliation>Institute of Liver Studies, Kings College Hospital, London, England.</nlm:affiliation>
<country>Royaume-Uni</country>
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<wicri:cityArea>Institute of Liver Studies, Kings College Hospital, London</wicri:cityArea>
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<author><name sortKey="Horsmans, Yves" sort="Horsmans, Yves" uniqKey="Horsmans Y" first="Yves" last="Horsmans">Yves Horsmans</name>
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<author><name sortKey="Sievert, William" sort="Sievert, William" uniqKey="Sievert W" first="William" last="Sievert">William Sievert</name>
<affiliation wicri:level="3"><nlm:affiliation>Gastroenterology and Hepatology Unit, Monash Medical Centre and Monash University, Melbourne, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Gastroenterology and Hepatology Unit, Monash Medical Centre and Monash University, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
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<author><name sortKey="Janczewska, Ewa" sort="Janczewska, Ewa" uniqKey="Janczewska E" first="Ewa" last="Janczewska">Ewa Janczewska</name>
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<country xml:lang="fr">Pologne</country>
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<author><name sortKey="Zeuzem, Stefan" sort="Zeuzem, Stefan" uniqKey="Zeuzem S" first="Stefan" last="Zeuzem">Stefan Zeuzem</name>
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<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Medicine I, Johann Wolfgang Goethe University Medical Center, Frankfurt am Main</wicri:regionArea>
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<region type="district" nuts="2">District de Darmstadt</region>
<settlement type="city">Francfort-sur-le-Main</settlement>
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<author><name sortKey="Nyberg, Lisa" sort="Nyberg, Lisa" uniqKey="Nyberg L" first="Lisa" last="Nyberg">Lisa Nyberg</name>
<affiliation wicri:level="2"><nlm:affiliation>Hepatology Research Department, Kaiser Permanente, San Diego, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Hepatology Research Department, Kaiser Permanente, San Diego</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Brown, Robert S" sort="Brown, Robert S" uniqKey="Brown R" first="Robert S" last="Brown">Robert S. Brown</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Hepatology and Gastroenterology, Columbia University College of Physicians and Surgeons, New York, New York.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Department of Hepatology and Gastroenterology, Columbia University College of Physicians and Surgeons, New York</wicri:cityArea>
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<author><name sortKey="Hezode, Christophe" sort="Hezode, Christophe" uniqKey="Hezode C" first="Christophe" last="Hézode">Christophe Hézode</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Hepatology and Gastroenterology, Hôpital Henri Mondor, Créteil</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Créteil</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rizzetto, Mario" sort="Rizzetto, Mario" uniqKey="Rizzetto M" first="Mario" last="Rizzetto">Mario Rizzetto</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Hepatology and Gastroenterology, University of Torino, Torino, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Hepatology and Gastroenterology, University of Torino, Torino</wicri:regionArea>
<placeName><settlement type="city">Turin</settlement>
<region type="région" nuts="2">Piémont</region>
</placeName>
</affiliation>
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<author><name sortKey="Parana, Raymundo" sort="Parana, Raymundo" uniqKey="Parana R" first="Raymundo" last="Paraná">Raymundo Paraná</name>
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<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Gastro-Hepatology Unit, Medical School, Federal University of Bahia, Bahia</wicri:regionArea>
<placeName><region type="state">Bahia</region>
</placeName>
</affiliation>
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<author><name sortKey="De Meyer, Sandra" sort="De Meyer, Sandra" uniqKey="De Meyer S" first="Sandra" last="De Meyer">Sandra De Meyer</name>
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<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Janssen Infectious Diseases BVBA, Beerse</wicri:regionArea>
<wicri:noRegion>Beerse</wicri:noRegion>
</affiliation>
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<author><name sortKey="De Masi, Ralph" sort="De Masi, Ralph" uniqKey="De Masi R" first="Ralph" last="De Masi">Ralph De Masi</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Luo, Donghan" sort="Luo, Donghan" uniqKey="Luo D" first="Donghan" last="Luo">Donghan Luo</name>
<affiliation wicri:level="2"><nlm:affiliation>Janssen Research & Development LLC, Titusville, New Jersey.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
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</placeName>
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<author><name sortKey="Bertelsen, Kirk" sort="Bertelsen, Kirk" uniqKey="Bertelsen K" first="Kirk" last="Bertelsen">Kirk Bertelsen</name>
<affiliation wicri:level="2"><nlm:affiliation>Janssen Research & Development LLC, Titusville, New Jersey.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
<wicri:cityArea>Janssen Research & Development LLC, Titusville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Witek, James" sort="Witek, James" uniqKey="Witek J" first="James" last="Witek">James Witek</name>
<affiliation wicri:level="2"><nlm:affiliation>Janssen Research & Development LLC, Titusville, New Jersey.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
<wicri:cityArea>Janssen Research & Development LLC, Titusville</wicri:cityArea>
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<series><title level="j">Gastroenterology</title>
<idno type="eISSN">1528-0012</idno>
<imprint><date when="2014" type="published">2014</date>
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<front><div type="abstract" xml:lang="en">We performed an open-label, multicenter, phase 3 study of the safety and efficacy of twice-daily telaprevir in treatment-naive patients with chronic hepatitis C virus (HCV) genotype 1 infection, including those with cirrhosis.</div>
</front>
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<name sortKey="De Meyer, Sandra" sort="De Meyer, Sandra" uniqKey="De Meyer S" first="Sandra" last="De Meyer">Sandra De Meyer</name>
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